I was trying to understand how does chronic diseases like cancer, some viral infections, MS and even drugs like the B-blockers cause fatigue. It is interesting that very little seems to be known about this very common phenomenon.There are a few proposed mechanisms for cancer-related fatigue including:
- proinflammatory cytokine hypothesis
-growth factors hypothesis
- circadian rhythm modulation hypothesis
- HPA axis disruption hypothesis
- serotonin dysregulation hypothesis
- vagal-afferent-activation hypothesis
- anemia hypothesis
- generation/use of ATP hypothesis
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